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For example, the behavior of cancer stem cells labeled with GFP and non-stem cells labeled with red fluorescent protein (RFP) can be simultaneously compared in vivo.
The OV100 contains an MT-20 light source (Olympus) and DP70 CCD camera (Olympus).
The optics of the OV-100 fluorescence imaging system have been specially developed for macroimaging as well as microimaging with high light-gathering capacity.
Kuhn in The Structure of Scientific Revolutions (3rd Edition, The University of Chicago Press, Chicago and London, 1996).
When the Nobel Prize in chemistry was awarded for the discovery of green fluorescent protein (GFP) in 2008, the Nobel Committee called GFP a guiding star for biochemistry enabling processes that were previously invisible, such as cancer cells spreading, to be strikingly visible.
Fluorescent proteins are so bright that simple equipment can be used for in vivo imaging.